Buy Roflumilast Online in Australia

What is Roflumilast

Roflumilast is a prescription medicine used to reduce flareups in adults with chronic obstructive pulmonary disease, particularly those who have a history of chronic bronchitis and frequent exacerbations. It belongs to the class of PDE-4 inhibitors. It is not a rescue inhaler and does not provide immediate relief from sudden breathlessness. For best results, it is used alongside inhaled therapies and healthy lifestyle choices.

How it works

The drug works by inhibiting the PDE-4 enzyme inside inflammatory cells in the airways. This raises cAMP levels, which lowers airway inflammation. With less inflammation, the lungs become less prone to flareups. The effect is gradual, so improvements in symptoms or fewer exacerbations appear over weeks to months rather than instantly.

How to take

The typical dose is 500 micrograms once daily. You can take it with or without food. Swallow the tablet whole; do not crush or chew. If you miss a dose, take it as soon as you remember the same day. If it is almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double up to make up for a forgotten dose.

Benefits and limits

In people with chronic bronchitis who have frequent COPD flareups, roflumilast can lower the number of exacerbations and may improve overall lung stability. It is not a cure for COPD, and it does not relieve acute symptoms. The medicine works best when combined with inhaled bronchodilators and anti inflammatory therapies as part of a comprehensive treatment plan.

Side effects and safety

Common side effects include nausea, diarrhea, weight loss, headache, and stomach discomfort. Some people also report insomnia, dizziness, or decreased appetite. A small number may experience mood changes, anxiety, or sleep problems. Very rarely, more serious psychiatric symptoms occur; seek help if thoughts of self harm or severe mood changes arise. Liver function tests may be monitored because the drug is processed by the liver.

Interactions and precautions

Roflumilast is metabolized by liver enzymes, mainly CYP3A4 and CYP1A2. Drugs that induce these enzymes can lower roflumilast levels and reduce effectiveness, while inhibitors can raise levels and raise side effect risk. Tell your healthcare provider about all medicines you take, including herbal supplements. Pregnancy and breastfeeding require medical advice before use. Avoid alcohol if you notice stomach upset or dizziness.

Who should not take it

Do not take roflumilast if you have moderate to severe liver impairment or a known allergy to the drug. It is not recommended for children. It should be used with caution in people with active mental health issues, and those with a history of depression or suicidal thoughts should discuss risks with their doctor before starting therapy.

Storage and monitoring

Store at room temperature away from moisture and heat. Keep the medication in its original container. Your doctor may check liver function and weight periodically while you are on roflumilast. If you notice persistent abdominal symptoms, unwanted weight loss, or new mood changes, contact your clinician promptly.