Package | Dosage | Price | Price per Dose | |
---|---|---|---|---|
Dosage: 150mg | ||||
56 pill | 150mg | AUD2,345.34 | AUD41.88 | |
28 pill | 150mg | AUD1,407.20 | AUD50.26 | |
Dosage: 200mg | ||||
56 pill | 200mg | AUD2,658.06 | AUD47.47 | |
28 pill | 200mg | AUD1,563.55 | AUD55.84 |
Nilotinib Description
What is Nilotinib?
Nilotinib is a targeted cancer medicine. It belongs to a class called tyrosine kinase inhibitors. It is used to treat specific blood cancers, mainly chronic myeloid leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). In practice, it is given to patients who have the BCR-ABL mutation. It is produced as capsules for oral use. This substance is available by prescription only and is supplied by pharmacies online with proper medical oversight. Patients should not self-medicate or switch brands without talking to a clinician. The information here is for overview only and does not substitute professional advice.
How Nilotinib works
Nilotinib blocks the BCR-ABL protein. This protein drives the growth of cancer cells. By blocking it, nilotinib slows or stops the growth of these cells. It may also affect other related kinases, which can influence healthy cells. The result is reduced cancer activity, but side effects can occur. The effect can take weeks to months to become noticeable. Regular blood tests monitor response and safety during treatment.
Administration and dosing
Nilotinib is taken as capsules. The usual dose for CML is 300 mg or 400 mg twice daily, depending on the specific condition and prior therapy. It should be swallowed whole with water. Do not chew or crush. Take the dose at least two hours after a meal and at least one hour before the next meal. If a dose is missed, contact the prescriber for instructions. Do not change the timing or amount without medical advice. Avoid grapefruit juice and certain supplements that can affect absorption or heart rhythm.
Who should use it and when
This medicine is prescribed by specialists for adults with CML or ALL with the BCR-ABL mutation. It is not suitable for everyone. People with heart rhythm issues, electrolyte problems, liver disease, or certain other health conditions need extra monitoring. Children are treated under pediatric specialist care with adjusted dosing. A doctor will determine if nilotinib is the best option after evaluating medical history and prior treatments. Ongoing assessments help decide if the therapy should continue or be switched.
Side effects and safety notes
Common side effects include headache, nausea, stomach upset, rash, and muscle or joint pain. Some people may have low white blood cell counts, anemia, or elevated liver enzymes. More serious risks include QT interval prolongation, changes in blood sugar, pancreatitis, and liver or heart toxicity. Report symptoms like fainting, chest pain, severe stomach pain, yellow skin, or dark urine to a clinician promptly. Regular ECGs and blood tests help detect problems early. Severe reactions require immediate medical attention.
Drug interactions and warnings
Nilotinib interacts with medications that affect heart rhythm, liver enzymes, or stomach pH. Tell the doctor about all medicines, vitamins, and herbal products. Avoid medicines that prolong the QT interval unless supervised. Antibiotics, antifungals, and some antidepressants may require dose changes. Do not drink alcohol excessively during treatment. Pregnancy and breastfeeding are not advised; use effective contraception and discuss family planning with a doctor. Ask about vaccines and other therapies that could interact with nilotinib safety.
Storage, disposal, and handling
Store in a cool, dry place away from light. Keep out of reach of children. Do not use outdated medicine. If you stop treatment, follow the doctor's plan. Return unused capsules to the pharmacy if allowed by local rules, and never flush medicines down the toilet unless instructed by healthcare providers. Handle capsules with dry hands and avoid exposing them to moisture or heat during preparation for administration.
Monitoring and follow-up
During treatment, doctors check blood counts, liver function, kidney function, and heart rhythm. They assess response by blood tests and sometimes bone marrow tests. ECGs may be done to monitor the heart's rhythm. Dose adjustments may be needed based on tolerance and lab results. Patients should report new symptoms promptly to maintain safety. Regular follow-up helps ensure the best possible outcome while managing risks.
Cost and access considerations
Nilotinib is a prescription medicine. Costs vary by country and dosage. Insurance coverage often applies. Online pharmacy services may require a valid prescription and pharmacist consultation. Some programs offer patient support for understanding dosing and safety. Always compare products and verify authenticity before purchase. Ask the pharmacist about generic options, patient assistance, and proper storage to maximize value and safety.